Lithium orotate is lithium bound to orotic acid, which improves its bioavailability. It is thought that some of the nutritional benefits of lithium come from its ability to support the synthesis and recycling of inositol, a primary component of the phosphoinositol signaling pathway. Research also shows that lithium supports the health and function of the hippocampus.

The addition of vitamin B12 and trimethylglycine (TMG) to Lithium Synergy helps support healthy methylation pathways; vitamin B12 is also needed for the synthesis of SAMe.